Development and disruption of atherosclerotic plaque and thrombus formation on disrupted plaque

Human Immunodeficiency Virus (HIV) and Coronary Atherosclerotic Plaque Formation: A Review

Chlamydia pneumoniae and atherosclerotic plaque.

To the Editor-According to Campbell et al. [1] in their recent study of Chlamydia pneumoniae in coronary tissue, staining with a Chlamydia-specific monoclonal antibody detected chlamydiae in 45% of the atherectomy specimens from patients with atherosclerotic plaque. However, staining appeared only in macrophages; smooth muscle cells did not stain, a result that appears to contradict previous fi...

Thrombus Formation on Disrupted Plaques

Acute cardiovascular events that usually involve thrombus formation at sites of disrupted atherosclerotic plaques are currently described as atherothrombosis. Thrombosis is a major complication of atherosclerosis and also a rare but serious complication after stent implantation. However, it does not always result in complete thrombotic occlusion with subsequent acute symptomatic events (1). The...

4 Atherosclerotic plaque rupture

The arterial system is more than an intricate plumbing system for the transport of blood; it is a highly complex organ that interacts with its environment. The major function of the vessel wall, and more specifically the endothelial lining, is to maintain an adequate blood supply to the end organ that it is supplying. This is achieved by regulatory mechanisms that control vascular tone, inflamm...

Vulnerable Atherosclerotic Plaque

Plaque Progression: Often Abrupt, Rarely Predictable Some facts are now certain. First, plaque progression and clinical outcome are not always closely related, and each is poorly predicted by clinical and angiographic variables.1–4 Second, many plaques progress episodically because of episodes of thrombosis triggered by rupture, erosion (denudation), or occasionally endothelial activation or in...